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Seahawks vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
22.5 Pts
Seahawks
21.0 Pts
Sunday September 7, 2025 at 4:05 PM ET
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SF
49ers Injury Report
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SEA
Seahawks Injury Report
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SF
49ers Lineup
Inactives
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SEA
Seahawks Lineup
Inactives
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SF
49ers News
#2 LDE
Yetur Gross-Matos: Limited in return to practice
Sep 4th
Gross-Matos (knee) was a limited participant in Thursday's practice.
#5 WR
Jordan Watkins: Back at practice Thursday
Sep 4th
Watkins (ankle) was a limited participant in Thursday's practice.
#4 RB
Jordan James: Limited in Thursday's practice
Sep 4th
James (finger) was a limited participant in Thursday's practice.
#1 WR
Jauan Jennings: Another limited showing
Sep 4th
Jennings (calf) practiced on a limited basis Thursday, Nick Wagoner of ESPN.com reports.
#1 RB
Christian McCaffrey: Pops up with calf injury
Sep 4th
McCaffrey was limited at Thursday's practice due to a calf injury, Cam Inman of The San Jose Mercury News reports.
#1 RG
Dominick Puni: Limited practice Wednesday
Sep 3rd
Puni (knee) was a limited participant at the 49ers' practice Wednesday, Cam Inman of The San Jose Mercury News reports.
#1 LG
Ben Bartch: Full practice Wednesday
Sep 3rd
Bartch (elbow) was a full participant at the 49ers' practice Wednesday, Cam Inman of The San Jose Mercury News reports.
#2 RDE
Sam Okuayinonu: Logs full practice Wednesday
Sep 3rd
Okuayinonu (shoulder) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#2 DT2
CJ West: Logs full practice Wednesday
Sep 3rd
West (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 SCB
Upton Stout: Recovered from calf injury
Sep 3rd
Stout (calf) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 LDE
Mykel Williams: Full participant in practice
Sep 3rd
Williams (knee) practiced in full Wednesday, Cam Inman of The San Jose Mercury News reports.
#1 FS
Jason Pinnock: Logs full practice
Sep 3rd
Pinnock (heel) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 RCB
Deommodore Lenoir: Recovered from hip injury
Sep 3rd
Lenoir (hip) was not listed on the 49er's injury report Wednesday, Cam Inman of The San Jose Mercury News reports.
#1 RDE
Nick Bosa: Fades injury report
Sep 3rd
Bosa (neck) was not listed on Wednesday's injury report, Cam Inman of The San Jose Mercury News reports.
#2 QB
Mac Jones: Past knee injury
Sep 3rd
Jones (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#3 RB
Isaac Guerendo: Full practice Wednesday
Sep 3rd
Guerendo (shoulder) practiced fully Wednesday, Cam Inman of The San Jose Mercury News reports.
#3 WR
Marquez Valdes-Scantling: Signed to active roster
Sep 2nd
The 49ers signed Valdes-Scantling to the active roster from the practice squad Tuesday, Aaron Wilson of KPRC 2 Houston reports.
#3 RCB
Jakob Robinson: Moves to IR
Aug 27th
Robinson (forearm) was placed on injured reserve Tuesday.
#8 WR
Jacob Cowing: Lands on injured reserve
Aug 27th
The 49ers placed Cowing (hamstring) on injured reserve Wednesday.
#3 LDT
Kevin Givens: Heads to IR
Aug 26th
Givens (pectoral) was placed on injured reserve Tuesday.
#3 FS
Malik Mustapha: Lands on PUP list
Aug 26th
Mustapha (knee) was placed on the reserve/PUP list Tuesday.
#3 QB
Kurtis Rourke: Shifts to NFI list
Aug 26th
Rourke (knee) was placed on the reserve/non-football injury list Tuesday.
#7 WR
Brandon Aiyuk: Shifts to reserve/PUP list
Aug 26th
The 49ers moved Aiyuk (knee) to the reserve/PUP list Tuesday.
#4 WR
Skyy Moore: Makes first grab with 49ers
Aug 23rd
Moore recorded three receptions on six targets for 19 yards in Saturday's 30-23 preseason win over the Chargers.
#6 WR
Demarcus Robinson: Closes preseason with score
Aug 23rd
Robinson (suspension) recorded two receptions on two targets for 30 yards and a touchdown in Saturday's 30-23 preseason win over the Chargers.
#1 TE
George Kittle: Not slated to suit up Saturday
Aug 23rd
Kittle isn't involved in warmups ahead of Saturday's preseason game against the Chargers, Matt Barrows of The Athletic reports.
#2 RB
Brian Robinson: Traded to 49ers
Aug 22nd
The Commanders are trading Robinson to the 49ers, Tom Pelissero of NFL Network reports.
SEA
Seahawks News
#1 RG
Anthony Bradford: Misses practice Thursday
Sep 4th
Bradford (back) did not participate at the Seahawks' practice Thursday, John Boyle of the team's official site reports.
#1 LCB
Riq Woolen: Under the weather
Sep 4th
Woolen did not participate in Thursday's practice due to an illness, John Boyle of the Seahawks' official site reports.
#5 WR
Dareke Young: Downgrades to DNP
Sep 4th
Young (hamstring) did not participate in Thursday's practice, John Boyle of the Seahawks' official site reports.
#1 RT
Abraham Lucas: Nabs extension from Seattle
Sep 4th
Lucas and the Seahawks agreed Thursday on a three-year, $46 million contract extension, Mike Garafolo of NFL Network reports.
#2 RDE
Mike Morris: Not listed on injury report
Sep 3rd
Morris (concussion) wasn't listed on Seattle's injury report Wednesday, John Boyle of the team's official site reports.
#1 LT
Charles Cross: Taken off injury report
Sep 3rd
Cross (finger) wasn't listed on Seattle's injury report Wednesday, John Boyle of the team's official site reports.
#1 LILB
Tyrice Knight: Not listed on injury report
Sep 3rd
Knight (knee) wasn't listed on Seattle's injury report Wednesday, John Boyle of the team's official site reports.
#2 SLB
Uchenna Nwosu: Limited in practice Wednesday
Sep 3rd
Nwosu (knee) was a limited participant in Seattle's practice Wednesday, John Boyle of the team's official site reports.
#6 WR
Cody White: Dealing with shoulder injury
Sep 3rd
White (shoulder) was a limited participant in Seattle's practice Wednesday, John Boyle of the team's official site reports.
#4 WR
Jake Bobo: Remains limited by concussion
Sep 3rd
Bobo (concussion) practiced in a limited capacity Wednesday, John Boyle of the Seahawks' official site reports.
#3 WR
Tory Horton: Logs full practice Wednesday
Sep 3rd
Horton (ankle) was a full practice participant Wednesday, John Boyle of the Seahawks' official site reports.
#2 RILB
Chazz Surratt: Joins Seahawks
Aug 28th
Surratt signed with the Seahawks on Thursday.
#2 RG
Christian Haynes: Placed on IR, designated to return
Aug 27th
Haynes (pectoral) was placed on injured reserve with a designation to return Tuesday, John Boyle of the Seahawks' official website reports.
#2 RCB
Derion Kendrick: Headed to Seattle
Aug 27th
Kendrick was claimed off waivers by the Seahawks on Wednesday, John Boyle of the team's official website reports.
#3 RDE
Rylie Mills: Starting career on NFI list
Aug 27th
Mills (knee) was moved to the reserve/non-football injury list Tuesday, John Boyle of the Seahawks' official site reports.
#2 NT
Johnathan Hankins: Starting season on NFI list
Aug 27th
Hankins (back) was moved to the reserve/non-football injury list Tuesday, John Boyle of the Seahawks' official site reports.
#3 RB
George Holani: Secures No. 3 job
Aug 27th
Holani was named the No. 3 running back after the Seahawks waived Damien Martinez on Tuesday, Michael-Shawn Dugar of The Athletic reports.
#3 QB
Jalen Milroe: Will get special package of plays
Aug 25th
Milroe will have a special set of plays installed in Seattle's offense for regular-season games, Bob Condotta of The Seattle Times reports.
#1 QB
Sam Darnold: Not playing in preseason finale
Aug 23rd
Darnold and other key players will be held out of Saturday's preseason finale at Green Bay, Brady Henderson of ESPN.com reports.